DNA Repair

MLH1 on chromosome 3p22.2 encodes a key component of the DNA mismatch repair system, forming the MutL alpha complex with PMS2 to c...

PALB2 Partner and Localizer of BRCA2 on chromosome 16p12.2 encodes a protein that links BRCA1 and BRCA2 at sites of DNA damage and...

ATM Ataxia Telangiectasia Mutated on chromosome 11q22.3 encodes a large serine threonine kinase of the PI3K related kinase family ...

CHEK2 on chromosome 22q12.1 encodes checkpoint kinase 2, a serine threonine kinase activated by ATM in response to DNA double stra...

WRN on chromosome 8p12 encodes Werner syndrome protein, a member of the RecQ family of DNA helicases that also has exonuclease act...

MSH2 on chromosome 2p21 encodes a core component of the DNA mismatch repair system, which corrects errors such as mispaired bases ...