Tumor Suppressor

BRCA1 Breast Cancer 1 is a tumor suppressor gene on chromosome 17q21.31. Its protein partners with BRCA2 and PALB2 in homologous r...

BRCA2 Breast Cancer 2 on chromosome 13q13.1 works with BRCA1 and PALB2 in homologous recombination DNA repair, where the BRCA2 pro...

TP53 on chromosome 17p13.1 encodes p53, the protein often called the guardian of the genome. It is the most frequently mutated gen...

RB1 on chromosome 13q14.2 was the first tumor suppressor gene to be cloned, in 1986, following the two hit hypothesis proposed in ...

PTEN on chromosome 10q23.31 encodes phosphatase and tensin homolog, a lipid phosphatase that converts PIP3 back to PIP2, opposing ...

APC Adenomatous Polyposis Coli on chromosome 5q22.2 is a tumor suppressor in the WNT signaling pathway. Its protein forms a destru...

VHL Von Hippel Lindau on chromosome 3p25.3 encodes the substrate recognition component of an E3 ubiquitin ligase that targets the ...

NF1 Neurofibromatosis type 1 on chromosome 17q11.2 encodes neurofibromin, a large GTPase activating protein that switches off RAS ...

TSC1, encoding hamartin on chromosome 9q34.13, and TSC2, encoding tuberin on chromosome 16p13.3, produce proteins that form a comp...

EXT1 on chromosome 8q24.11 and EXT2 on chromosome 11p11.2 encode glycosyltransferases that work together in the Golgi apparatus to...

WT1 on chromosome 11p13 encodes a zinc finger transcription factor, existing in multiple isoforms, that is essential for the devel...

MEN1 on chromosome 11q13.1 encodes menin, a nuclear protein that interacts with many transcription factors and chromatin modifying...

CDKN2A on chromosome 9p21.3 is an unusual gene that encodes two distinct tumor suppressor proteins from overlapping sequences read...

NF2 on chromosome 22q12.2 encodes merlin, also called schwannomin, a cytoskeleton associated tumor suppressor that helps cells sto...